COVID-19-COS is conducted as part of the National COVID-19 Clinical Evidence Taskforce by the Australian Living Evidence Consortium to ensure that consensus-based high priority outcomes are consistently included in guidelines for the clinical management of patients with suspected or proven COVID-19 infection across primary, acute and critical care settings. The COS is also intended to be implemented in trials in people with suspected or confirmed COVID-19.
PHASE 1 | Systematic review of outcomes in registered and published trials in patients with confirmed or suspected 2019-nCoV
We will conduct a systematic review to identify and assess the scope and consistency of outcomes reported in randomised controlled trials (RCTs) of interventions in patients with confirmed or suspected COVID-19.
PHASE 2 | Delphi survey
We will conduct an international online two-round Delphi survey with patients, caregivers, community members and health professionals to gain consensus on the outcome domains that are critically important to all stakeholder groups for trials in COVID-19.
PHASE 3 | Consensus workshops
We will conduct a series of three web-based consensus workshops on zoom over three consecutive days (each workshop will be 2 hours in duration with approximately 60 patients, caregivers, community members and health professionals; total 180) to obtain feedback and discuss the proposed core outcomes for COVID-19. The online consensus workshops will be conducted in English chaired by a member of investigator team.
To establish a core outcome set for research in patients with confirmed or suspected 2019-nCoV.Contributors
Julian Elliot, Monash University and Cochrane Australia
Jonathan Craig, Flinders University
Armando Teixeira-Pinto, The University of Sydney
Martin Howell, The University of Sydney
Allison Tong, The University of Sydney
- COS for clinical trials or clinical research
- Consensus conference
- Delphi process
- Literature review
Systematic review of outcomes reported in registered and published trials
International two-round Delphi survey
Three consecutive online consensus workshops
Stakeholder groups - ALL – its open to all given the nature of the condition