Core Outcome Measures in Effectiveness Trials

Developing a Core Outcome Set for Children with Chronic Wet Cough

General Information

Summary:
The aim of this project is to develop a Core Outcome Set for the treatment of chronic wet cough in children (excluding cystic fibrosis) which can be used in clinical and cost effectiveness studies. This will be undertaken in accordance with the Core Outcome Sets - Standards for Development (COS-STAD) document.

Contributors:
Imran Ali(1), Charlotte King(2), Carly Greene(3), Will Carroll(1,4), Malcolm Brodlie (5,6), Ian Sinha (2) & Francis Gilchrist (1,4)

Institutions:
1. Academic Department of Child Health, Royal Stoke University Hospital, University Hospitals of North Midlands NHS Trust, Stoke on Trent, ST4 6QG, UK
2. Department of Paediatric Respiratory Medicine, Alder Hey Children’s Hospital, Liverpool, L14 5AB
3. West Midlands Clinical Research Network - NIHR, Unit 9 1st Floor, Frank Foley Way, Greyfriars Business Park, Stafford, ST16 2ST
4. Institute of Applied Clinical Science, Keele University, Keele, ST5 5BG.
5. Department of Paediatric Respiratory Medicine, Great North Children’s Hospital, Newcastle upon Tyne, NE1 4LP.
6. Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne.

Dr Francis Gilchrist is the Principal Investigator

Further Study Information

Current Stage:
Ongoing
Date:
October 2018
Funding source(s):
None

Health Area

Disease Category
Child health
Lungs & airways

Disease Name
Chronic wet cough

Target Population

Age Range
1 - 14

Sex
Either


Nature / type of Intervention
Any

Method(s)

Consensus meeting
Delphi process
Interview
Semi structured discussion
Systematic review

1. Systematically review current literature to identify outcomes used in previous intervention studies for children with chronic wet cough.
2. Identify outcomes important to parents of children with chronic wet cough through semi structured interviews and outcomes important to children with chronic wet cough through group discussions.
3. Conduct Delphi survey with key stakeholders to prioritise outcomes. Stakeholders will include general practitioners, paediatric respiratory nurse specialists, secondary care paediatricians and tertiary care respiratory paediatricians.
4. Hold a consensus meeting where the prioritised outcome list will be discussed between key stakeholders and parent/child representatives to generate a COS.


Stakeholders Involved

Clinical experts
Consumers (caregivers)
Consumers (patients)
Families
Researchers

Study Type

COS for clinical trials or clinical research

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