Core Outcome Measures in Effectiveness Trials

Outcome Reporting in Thumb Trapeziometacarpal Arthritis: A Systematic Review

General Information

Summary:
The aim of this project is a systematic review of all outcomes and outcome measures previously reported in thumb cmc joint arthritis. This will then inform the development of a COS in a later project.

Contributors:
Andrea Copeland
Lucas Gallo, BHSc, MD (Cand) 2
Matteo Gallo, BHSc (Cand) 3
Daniel Waltho, MD 1
Charmaine Baxter, MD 1
Marta Karpinski BHSc 3
Sadek Mowakket BHSc (Cand) 3
Jessica Murphy, MSc 1
Achilleas Thoma, MD, MSc 1,4,5

Affilitations
1. Division of Plastic Surgery, Department of Surgery, McMaster University
2. Faculty of Medicine, McMaster University
3. Faculty of Health Sciences, McMaster University
4. Department of Health Research Methods, Evidence, and Impact, McMaster University
5. Surgical Outcomes Research Centre, McMaster University

Further Study Information

Current Stage:
Ongoing
Date:
March 2018 - January 2019
Funding source(s):
None

Health Area

Disease Category
Rheumatology

Disease Name
Thumb carpometacarpal joint arthritis

Target Population

Age Range
18 - 100

Sex
Either


Nature / type of Intervention
Surgery

Method(s)

Systematic review

Inclusion Criteria:
1. Primary studies (randomized control trials and non-randomized controlled studies) written in English
2. The treatment is a surgical procedure including one of: trapeziectomy, trapeziectomy with TI, trapeziectomy with LR, trapeziectomy with LRTI, CMC arthrodesis, joint replacement, Artelon joint resurfacing, volar ligament reconstruction, metacarpal osteotomy, autologous fat transfer, denervation
3. Studies must include at least one well-described outcome and/or outcome measure

Exclusion Criteria:
1. Cohort and case control studies with n<50, descriptive studies, anecdotes and case reports
2. Exclude studies comparing non-surgical management with surgery

Search Strategy:
The electronic databases 1) OVID Medline Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R) 1946 to Present, 2) Embase 1974 to Present, 3) Cochrane Library, and 4) CINAHL were searched with the following search terms:

Screening:
Following the removal of duplicates, two review authors will independently review the titles and abstracts of all retrieved articles based on the aforementioned inclusion and exclusion criteria. Full-text documents of potentially relevant reports will be retrieved and independently assessed for inclusion by 2 reviewers. Disagreements will be resolved by consensus between the two review authors and further discordance will be settled by a third author. Review authors will not be blinded to author(s), institution or site of publication. Authors of documents requiring further information or delineation will be contacted if necessary. Inter-rater agreement will be calculated using Kappa statistics.

Data Extraction:
Prior to data extraction, a representative sample of articles will be piloted to ensure that participating authors are retrieving similar results. Two review authors will independently perform data extraction in duplicate, based on a data collection form designed a priori. Disagreements will be resolved through discussion between the two review authors; further discordance will be settled by a third author. Completed data collection forms will include study characteristics, list of all outcomes and outcome measures included, and information on the types of outcomes and outcome measurements included. Inter-rater agreement will be calculated using Kappa statistics. Data will be extracted from papers included in the review using the standardized data extraction tool.

Data Synthesis:
Outcomes and outcome measures will be grouped (e.g. subjective vs. objective, patient- vs. clinician-reported, cost-related, quality of life measures, etc.) to help organize and summarize the data.


Stakeholders Involved

None

Study Type

Systematic review of outcomes measured in trials

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