Core Outcome Measures in Effectiveness Trials

Development of a Core Outcome Set for Dupuytren's disease

General Information

Summary:
Dupuytren’s disease is a fibroproliferative disorder of the palmar and digital fascia, with an estimated prevalence of 7.3%. The diseased fascia leads to a progressive contracture of one or more digits, limiting range of motion, and impairing hand function. Currently, there is no recommended standard set of outcomes to report in Dupuytren’s disease treatment studies, nor are there guidelines on how the outcomes themselves should be reported.
This study aims to identify an exhaustive list of outcomes and outcome measures used to evaluate postoperative results for Dupuytren's disease. The identified list of outcomes will then be used for the development of a core outcome set (COS).

To create the COS, we will use the Delphi Process, an iterative survey-based method using various stakeholder groups. Our stakeholders will include patients, surgeons, nurses, physiotherapists, and occupational therapists. We will conclude with a final consensus meeting, whereby an agreement of 70% must be met for the item to appear on the Core Outcome Set.

Contributors:
Marta Karpinski(2), Syena Moltaji(1), Charmaine Baxter(3), Jo-Anne Petropoulos(3), Jessica Murphy(3), Andrea Copeland(3), Lucas Gallo (3), Daniel Waltho (3), Achilleas Thoma(3,4,5)*

1. Faculty of Medicine, McMaster University
2. Faculty of Health Sciences, McMaster
3. Division of plastic surgery, McMaster
4. Department of health research methods, evidence and impact, McMaster
5. Surgical Outcome Research Centre, McMaster
*Principal Investigator

Further Study Information

Current Stage:
Ongoing
Date:
2018 - 2019
Funding source(s):
None

Health Area

Disease Category
Orthopaedics & trauma

Disease Name
Dupuytren's disease

Target Population

Age Range
18 - 100

Sex
Either


Nature / type of Intervention
Surgery

Method(s)

Consensus meeting
Delphi process
Focus group(s)
Interview
Semi structured discussion
Systematic review

Consensus meeting
Delphi process
Interview
Systematic review
A systematic review was conducted to identify an exhaustive list of outcomes and outcome measures in Dupuytren's disease. The identified list of outcomes will then be used a starting point for the development of the COS.

To create the COS, we will use the Delphi Process, an iterative survey-based method using various stakeholder groups. Our stakeholders will include patients, surgeons, nurses, physiotherapists, and occupational therapists. We will conclude with a final consensus meeting, whereby an agreement of 70% must be met for the item to appear on the Core Outcome Set.


Stakeholders Involved

Clinical experts
Consumers (patients)
Epidemiologists
Statisticians

Study Type

COS for clinical trials or clinical research

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