Patient reported outcome measures in trigeminal neuralgia – A systematic review of psychometric performance

Background
Trigeminal neuralgia (TN) is a rare condition for which there are multiple treatment options available. To date, there has been difficulty in comparing the outcomes of treatment due to the variety of patient-reported outcome measures (PROMs) and their inadequate psychometric testing. The aim of this review was to assess the psychometric properties of PROMs used to date in TN and make recommendations for their use in future studies.

Methods
Five electronic databases (MEDLINE, EMBASE, CINAHL Plus, PsycINFO, Health and Psychosocial Instruments) were searched for studies assessing the development of PROMs or their psychometric properties in TN studies. The records obtained were assessed independently by two reviewers for their methodological quality, following guidance from the Consensus-based Standards for the selection of Health Measurement Instruments (COSMIN).

Results
Six studies were identified and information on five PROMs (Brief Pain Inventory Facial (BPI-F), Visual Analogue Scale (VAS), Barrow Neurology Institute Pain Scale (BNI-PS), Penn Facial Pain Scale-Revised (Penn-FPS-R) and Trigeminal Neuralgia Quality of Life Score) were retrieved. The Penn-FPS-R demonstrated moderate quality evidence for sufficient content validity. The BPI-F showed moderate evidence for sufficient internal consistency and structural validity but low evidence for inconsistent content validity. The Trigeminal Neuralgia Quality of Life score showed very low-quality evidence for insufficient content validity, structure validity and responsiveness. No evidence was found on the assessment of any psychometric properties of the VAS and BNI-PS in TN.

Conclusion
There is limited evidence of the psychometric performance of patient-reported outcomes for TN and recommendations for their inclusion in future studies cannot be made. The validation of PROMs in TN studies should be a priority in this field of research.

Significance
This review highlights the knowledge gap in the field of psychometrics of patient reported outcomes measures in the field of TN. Given the unavailability of an objective outcome measure for pain or health related quality of life, psychometrically sound PROMs are essential for assessing medical and surgical treatment outcomes in TN.

Contributors

Carolina Venda Nova, Joanna M. Zakrzewska, Sarah R. Baker, Richeal Ni Riordain

Publication

Journal: European Journal of Pain
Volume: 25
Issue:
Pages: 1449 - 1461
Year: 2021
DOI: 10.1002/ejp.1779

Further Study Information

Current Stage: Completed
Date:
Funding source(s): This work was supported by the Trigeminal Neuralgia Association UK (TNAUK) and by the Rosetrees Trust (grant A2327).


Health Area

Disease Category: Dentistry & oral health

Disease Name: Trigeminal neuralgia

Target Population

Age Range: 18 - 100

Sex: Either

Nature of Intervention:

Stakeholders Involved

Study Type

- Systematic review of outcome measures/measurement instruments

Method(s)

- Systematic review