Background: There is a lack of consensus related to the collection of standardized data for individuals with vitiligo enrolled in clinical trials and registries as well as those seen in clinical practice which causes difculty in accurately interpreting, comparing, and pooling of data.
Several years ago, eforts to initiate work on developing core outcome sets were performed and a consensus was reached in 2015 on the frst core domain set for vitiligo clinical trials.
Methods/design: This project aims to further develop a core outcome set for vitiligo clinical trials as well as create internationally agreed-upon core outcome sets for registries and clinical practice. These core outcome sets will include a core domain set and a core measurement instruments set and will be supplemented by contextual factors, including baseline and treatment-related characteristics. In a preparatory exercise, the 2015 core domain set will be re-evaluated and will serve as the basis for the list of outcome domains used to initiate the consensus process. This project will consist of two parts. Part 1 will focus on the selection of a core domain set, or “what to measure” and contextual factors, for each setting based on electronic surveys (e-Delphi technique) and a conclusive consensus meeting by a large group of international stakeholders. Part 2 will include selection of core measurement instruments, or “how to measure,” and measurement details (e.g., scale and timing) for the core domain sets and contextual factors agreed upon in part 1. Part 2 will be based on consensus meetings with stakeholders involved in part 1 and will be guided
by C3 (CHORD-COUSIN Collaboration), Harmonising Outcome Measures for Eczema (HOME), COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN), and Outcome Measures in Rheumatology (OMERACT) recommendations including information on measurement properties of available instruments (systematic review and expert/patient opinion). At the end of part 2, all stakeholders involved will be invited to participate in a fnal meeting in which the ultimate core data sets (core outcome sets and contextual factors) will be presented and the dissemination plan and implementation goals will be defined.
Discussion: This project will harmonize data collection between clinical trials, registries, and clinical practices, facilitating new insights in vitiligo.
Trial registration: This study is registered in the Core Outcome Measures for Effectiveness Trials (COMET) database and on the C3 (CHORD-COUSIN Collaboration) website
Tis project aims to further develop international consensus on a core outcome set in vitiligo clinical trials for all vitiligo treatments, applicable to full-body/regional evaluation and in a second step for target lesions, as well as create internationally agreed-upon core outcome sets
for registries and clinical practice.
Nanja van Geel, Iltefat H. Hamzavi, Amit G. Pandya, Albert Wolkerstorfer, Julien Seneschal, Amit Garg, Phyllis Spuls, Caroline B. Terwee, Sue Mallett, Reinhart Speeckaert, Jean Marie Meurant, Viktoria Eleftheriadou, and Khaled Ezzedine
Disease Category: Skin
Disease Name: Vitiligo
Age Range: Unknown
Sex: Either
Nature of Intervention: Any
- Clinical experts
- Consumers (patients)
- Journal editors
- Methodologists
- Other
- Patient/ support group representatives
- Researchers
- COS for clinical trials or clinical research
- COS for practice
- COS for registry
- Consensus meeting
- Delphi process
- Focus group(s)
- Literature review
- Trial registry
The composition of this comprehensive list will be based on the previously (2015) defined list of core domains and their possible domain items for trials, (1) additional literature search (including a search in ClinicalTrials.gov and (2) review of vitiligo guidelines (from various countries if relevant)), (3) variables gathered by vitiligo experts in existing clinics and existing clinical registries, and (4) expert and patient opinions. The additional list will be used for a delphi consensus process